topic 05. MSA approximation algorithm

The variation of the algorithms, which one is better?

​PRESENTATION2: MAFFT

​How to score MSA?

​Another issue: huge amount data

• Supporting Materials

  1. PSI/TM-Coffee web server

  2. PSI/TM-Coffee: Floden, E. W. et al. PSI/TM-Coffee: a web server for fast and accurate multiple sequence alignments of regular and transmembrane proteins using homology extension on reduced databases. Nucleic Acids Res. 44, W339–43 (2016).

  3. PSI-Coffee: ​Chang, J.-M. M., Di Tommaso, P., Taly, J.-F. F. & Notredame, C. Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee. BMC Bioinformatics 13 Suppl 4, S1 (2012).