topic 9. Protein secondary structure prediction

RCSB Protein Data Bank (PDB)

​Neural network approach

Knowledge-based approach

• Supporting Materials

  1. Protein 3D structure prediction

     • Protein-structure prediction revolutionized by Nature News

     • AlphaFold

     • RoseTTA

     • Popular Science Articles

       • AlphaFold: a solution to a 50-year-old grand challenge in biology, DeepMind, 2020-11-03

       • 兩大頂級AI演算法開源, TechOrange, 2021-07-19

       • AlphaFold2 預測準度逼近滿分, TechOrange, 2021-07-22

  2. PDB

  3. HYPROSP: Wu, K.-P., Lin, H.-N., Chang, J.-M., Sung, T.-Y. & Hsu, W.-L. HYPROSP: a hybrid protein secondary structure prediction algorithm—a knowledge-based approach. Nucleic Acids Research 32, 5059–5065 (2004).

  4. HYPROSPII: Lin, H.-N., Chang, J.-M., Wu, K.-P., Sung, T.-Y. & Hsu, W.-L. HYPROSP II-A knowledge-based hybrid method for protein secondary structure prediction based on local prediction confidence. Bioinformatics 21, 3227–3233 (2005).​